A combined array-based comparative genomic hybridization (aCGH) and functional library screening approach identifies mir-30d as an oncomir in cancer
نویسندگان
چکیده
1. Ovarian Cancer Research Center and Department of Obstetrics & Gynecology; 2. Abramson Family Cancer Research Institute; University of Pennsylvania, Philadelphia, PA 19104; 3. Department of Obstetrics & Gynecology and Pathology, University of Helsinki and Helsinki University Central Hospital, Finland; 4. Institute of Modern Physics, Chinese Academy of Science, Lanzhou, China; 5. Department of Obstetrics and Gynecology, University of Turin, Turin, Italy; 6. Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104
منابع مشابه
A combined array-based comparative genomic hybridization and functional library screening approach identifies mir-30d as an oncomir in cancer.
Oncomirs are microRNAs (miRNA) that acts as oncogenes or tumor suppressor genes. Efficient identification of oncomirs remains a challenge. Here we report a novel, clinically guided genetic screening approach for the identification of oncomirs, identifying mir-30d through this strategy. mir-30d regulates tumor cell proliferation, apoptosis, senescence, and migration. The chromosomal locus harbor...
متن کاملMolecular and Cellular Pathobiology ACombinedArray-BasedComparativeGenomicHybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer
Oncomirs aremicroRNAs (miRNA) that acts as oncogenes or tumor suppressor genes. Efficient identification of oncomirs remains a challenge. Here we report a novel, clinically guided genetic screening approach for the identification of oncomirs, identifying mir-30d through this strategy. mir-30d regulates tumor cell proliferation, apoptosis, senescence, and migration. The chromosomal locus harbori...
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